Protracted use of acetaminophen (1 week) may suppress fetal testosterone production, which could have adverse consequences.

PMID:  Sci Transl Med. 2015 May 20 ;7(288):288ra80. PMID: 25995226 Abstract Title:  Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model. Abstract:  Most common male reproductive disorders are linked to lower testosterone exposure in fetal life, although the factors responsible for suppressing fetal testosterone remain largely unknown. Protracted use of acetaminophen during pregnancy is associated with increased risk of cryptorchidism in sons, but effects on fetal testosterone production have not been demonstrated. We used a validated xenograft model to expose human fetal testes to clinically relevant doses and regimens of acetaminophen. Exposure to a therapeutic dose of acetaminophen for 7 days significantly reduced plasma testosterone (45% reduction; P = 0.025) and seminal vesicle weight (a biomarker of androgen exposure; 18% reduction; P = 0.005) in castrate host mice bearing human fetal testis xenografts, whereas acetaminophen exposure for just 1 day did not alter either parameter. Plasma acetaminophen concentrations (at 1 hour after the final dose) in exposed host mice were substantially below those reported in humans after a therapeutic oral dose. Subsequent in utero exposure studies in rats indicated that the acetaminophen-induced reduction in testosterone likely results from reduced expression of key steroidogenic enzymes (Cyp11a1, Cyp17a1). Our results suggest that protracted use of acetaminophen (1 week) may suppress fetal testosterone production, which could have adverse consequences. Further studies are required to establish the dose-response and treatment-duration relationships to delineate the maximum dose and treatment period without this adverse effect.

Oridonin could exert anti-cancer effects on tumor growth in human glioma by inducing cell cycle arrest and eventual cell apoptosis.

PMID:  Cell Mol Biol (Noisy-le-grand). 2014 ;60(6):29-36. Epub 2014 Dec 30. PMID: 25553351 Abstract Title:  Oridonin inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis. Abstract:  Glioma is the most common malignant intracranial tumors. Despite newly developed therapies, these treatments mainly target oncogenic signals, and unfortunately, fail to provide enough survival benefit in both human patients and mouse xenograft models, especially the first-generation therapies. Oridonin is purified from the Chinese herb Rabdosia rubescens and considered to exert extensive anti-cancer effects on human tumorigenesis. In this study, we systemically investigated the role of Oridonin in tumor growth and the underlying mechanisms in human glioma. We found that Oridonin inhibited cell proliferations in a dose- and time-dependent manner in both glioma U87 and U251 cells. Moreover, these anti-cancer effects were also confirmed in a mouse model bearing glioma. Furthermore, cell cycle arrest in S phase was observed in Oridonin-mediated growth inhibition by flow cytometry. Cell cycle arrest in S phase led to eventual cell apoptosis, as revealed by Hoechst 33342 staining and annexin V/PI double-staining. The cell apoptosis might be accomplished through a mitochondrial manner. In all, we were the first to our knowledge to report that Oridonin could exert anti-cancer effects on tumor growth in human glioma by inducing cell cycle arrest and eventual cell apoptosis. The identification of Oridonin as a critical mediator of glioma growth may potentiate Oridonin as a novel therapeutic strategies in glioma treatments.

Vegetable Extract Treats Autism Better Than Drugs

Written By:

Sayer Ji, Founder

The CDC says there is no treatment for autism, but this vegetable extract significantly improved the condition in a recent clinical trial.

Presently, autism spectrum disorder (ASD) is considered a condition with no known conventional treatment. According to the CDC: "There are no medications that can cure ASD or treat the core symptoms."[1] With a prevalence rate in the U.S. estimated to be 1 in every 68 children,[2] a growing number of families are actively searching for safe, affordable and effective interventions.

Thankfully, and despite the failings of pharmaceutical-based medicine, there are natural interventions that have been studied and appear to hold great promise. For instance, we have indexed research from the National Library of Medicine on over 30 natural substances that may play a role in improving the condition. You can view these study abstracts on our Autism Spectrum Disease research database, and you will also find a list there of over 20 substances that should be avoided there, including heavy metals in vaccines and common dietary components like gluten.

Broccoli Extract Does The "Impossible": Improves Autism Spectrum Disorder

Of all the natural substances we have reviewed with potential value in the treatment of ASD, sulforaphane, a molecule found in cruciferous vegetables such as broccoli, cabbage and Brussels sprouts, is perhaps the most promising candidate.

A groundbreaking study published in 2014 in The Proceedings of the National Academy of Sciences USA titled, "Sulforaphane treatment of autism spectrum disorder (ASD)," found that a broccoli sprout extract significantly improved the behavior of boys and men with ASD. The researchers pointed out that, presently, no conventional, mechanism-based treatment is available for ASD. Sulforaphane was selected, in part, because its physiological effects are well characterized and ideal for those with ASD:

Dietary sulforaphane, of recognized low toxicity, was selected for its capacity to reverse abnormalities that have been associated with ASD, including oxidative stress and lower antioxidant capacity, depressed glutathione synthesis, reduced mitochondrial function and oxidative phosphorylation, increased lipid peroxidation, and neuroinflammmation."

The placebo-controlled, randomized pilot study of 44 males, ages 13-27, showed that after 18 weeks of treatment with a sulforaphane-rich broccoli sprout extract, 46% had significant improvements in social interactions and 42% has significant improvements in verbal communication.

Additionally, more than half the participants showed decreases in abnormal behaviors, including irritability, hyperactivity and repetitive movements. Of note, once treatment stopped, most of the behaviors returned to pretreatment levels. For more details on the study, read a Medscape report on the study, including an interview with the study's lead researcher.

The dosing schedule was determined by body weight:

• 100 lbs or less: one capsule containing 50 µmol (232 mg) of sulforaphane-rich broccoli extract was given daily
• 101–199 lbs, 100 µmol (two capsules of 232 mg each) of sulforaphane-rich broccoli extract was given daily
• More than 200 lbs: 150 µmol (three capsules of 232 mg each) of sulforaphane-rich broccoli extract was given daily

Sulforaphane: A Largely Ignored Panacea-like Phytocompound

It may come as a surprise to many reading this that so simple and natural a substance as broccoli extract could have significant therapeutic value in a condition which is considered refractory to conventional treatment and whose causes, including vaccines, are considered politically incorrect to discuss, despite evidence provided by one of the CDC's senior vaccine scientists to support the connection.

But the truth is that sulforaphane is no newcomer to the medical research community. It happens to be one of the most extensively studied and promising natural substances in existence. You will find over 1200 published studies on pubmed.gov and you'll find an archive of over 200 citations on our database indicating its value in a staggering 150 different conditions.

Keep in mind that sulforaphane concentrations are several hundred times higher in the broccoli sprout versus mature broccoli. There are now a wide range of manufacturers that produce broccoli sprout extract making it all the more convenient to obtain and administer a therapeutic dose.

Vani Hari Review Focusing On Fast Weight Loss

The Food Babe Way: Break Free from the Hidden Toxins in Your Food and Lose Weight, Look Years Younger, and Get Healthy in Merely 21 Days!

A #1 National Bestseller! Cut hidden food toxins, slim down, and get healthy and balanced in just 21 days.

Did you know that your fast food fries include a chemical made use of in Silly Putty? Or that a juicy peach doused greatly with pesticides could be triggering your body to accumulate fat?

When we go to the grocery store, we rely on that all our items purchased are okay to consume. But a lot of just what we're putting into our physical bodies is either tainted with chemicals or processed in a manner that makes us gain weight, feel ill, as well as age before our time.

Thankfully, Vani Hari - also known as the Food Babe - has actually got your back. A food activist that has courageously put the heat on huge food business to divulge active ingredients and eliminate harmful additives from their food lines, Hari has actually made it her life's objective to inform the world concerning how to live a clean, organic, healthy way of life in an overprocessed, contaminated-food world, and how to look and feel wonderful while doing it.

In THE FOOD BABE WAY, Hari invites you to follow an easy and available plan to clear your body of toxins, reduce weight without counting calories, and also recover your natural radiance in only 21 days.

Consisting of anecdotes of her very own makeover along with easy-to-follow grocery shopping lists, meal strategies, and also mouthwatering unique recipes, THE FOOD BABE WAY will encourage you to transform your food, transform your physical body, and also transform the world around us.

As a fellow author, I personally recommend Vani's publication as it's based on the exact same principles as my book, The Path To True Health And Optimal Wellness. We both think exactly what you place in your mouth impacts your wellness, favorably or negatively, so choose intelligently!

She provides an in depth food guide and also an eating strategy along with recipes that make it easy for an individual to stay focused and attain their health objectives. Just follow her plan and change your wellness. If you can follow instructions, you can do this.

She has actually taken the hard work out of the equation and offered you the blueprint. The remainder is up to you, are you prepared to transform your wellness?